Neural activity promotes long-distance, target-specific regeneration of adult retinal axons
نویسندگان
چکیده
منابع مشابه
Guiding adult Mammalian sensory axons during regeneration.
Misdirection of axons after nerve injury impairs successful regeneration of adult neurons. Investigations of axon guidance in development have provided an understanding of pathfinding, but their relevance to regenerating adult axons is unclear. We investigated adult mammalian axon guidance during regeneration after peripheral nerve injury and focused on the effects of the prototypic guidance mo...
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Following a nerve crush, damaged frog motor axons regenerate to reinnervate their denervated muscle fibre targets. The axons do this by growing down their old nerve tubes to their former synaptic sites. It is the naked basal lamina of the nerve tube that appears to direct the regenerating axons by providing a substratum over which the axons will preferentially grow. Another possible mechanism f...
متن کاملAxonal regeneration of retinal ganglion cells depending on the distance of axotomy in adult hamsters.
PURPOSE To examine the relationship between the distance of axotomy and axonal regeneration of injured retinal ganglion cells (RGCs) systematically and the effect of a predegenerated (pretransected or precrushed) peripheral nerve (PN) graft on axonal regeneration of RGCs axotomized at a definite distance (0.5 mm from the optic disc) in comparison with a normal PN graft. METHODS The optic nerv...
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Native fibroblast growth factor receptor (FGFR) function was inhibited in developing Xenopus retinal ganglion cells (RGCs) by in vivo transfection of a dominant negative FGFR. Axons expressing the dominant negative protein advanced at 60% of the normal speed, but nevertheless navigated appropriately in the embryonic optic pathway. When they neared the optic tectum, however, many axons made erro...
متن کاملApplication of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats.
Inactivation of Rho promotes neurite growth on inhibitory substrates and axon regeneration in vivo. Here, we compared axon growth when neuronal cell bodies or injured axons were treated with a cell-permeable Rho antagonist (C3-07) in vitro and in vivo. In neurons plated in compartmented cultures, application of C3-07 to either cell bodies or distal axons promoted axonal growth on myelin-associa...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2016
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.4340